Plaxidol
Brand names,
Plaxidol
Analogs
Plaxidol
Brand Names Mixture
Plaxidol
Chemical_Formula
C21H27ClN2O2
Plaxidol
RX_link
http://www.rxlist.com/cgi/generic/hydrox.htm
Plaxidol
fda sheet
Plaxidol
msds (material safety sheet)
Plaxidol
Synthesis Reference
Moren; U.S. Pat. 2,899,436 (1959)
Plaxidol
Molecular Weight
374.904 g/mol
Plaxidol
Melting Point
190 oC
Plaxidol
H2O Solubility
< 700 mg/mL
Plaxidol
State
Solid
Plaxidol
LogP
3.036
Plaxidol
Dosage Forms
Capsule; Liquid; Solution; Syrup
Plaxidol
Indication
For symptomatic relief of anxiety and tension associated with psychoneurosis and as an adjunct in organic disease states in which anxiety is manifested. Useful in the management of pruritus due to allergic conditions such as chronic urticaria.
Plaxidol
Pharmacology
Hydroxyzine, a piperazine antihistamine structurally related to buclizine, cyclizine, and meclizine, is used to treat histamine-mediated pruritus or pruritus due to allergy, nausea and vomiting, and, in combination with an opiate agonist, anxiolytic pain. Hydroxyzine is also used as a perioperative sedative and anxiolytic and to manage acute alcohol withdrawal. Hydroxyzine's active metabolite, cetirizine, is also used as an H1-antagonist.
Plaxidol
Absorption
Rapidly absorbed from the gastrointestinal tract
Plaxidol
side effects and Toxicity
Oral, rat LD50: 950 mg/kg. Symptoms of overexposure include hypersedation.
Plaxidol
Patient Information
Plaxidol
Organisms Affected
Humans and other mammals