Aterax
Brand names,
Aterax
Analogs
Aterax
Brand Names Mixture
Aterax
Chemical_Formula
C21H27ClN2O2
Aterax
RX_link
http://www.rxlist.com/cgi/generic/hydrox.htm
Aterax
fda sheet
Aterax
msds (material safety sheet)
Aterax
Synthesis Reference
Moren; U.S. Pat. 2,899,436 (1959)
Aterax
Molecular Weight
374.904 g/mol
Aterax
Melting Point
190 oC
Aterax
H2O Solubility
< 700 mg/mL
Aterax
State
Solid
Aterax
LogP
3.036
Aterax
Dosage Forms
Capsule; Liquid; Solution; Syrup
Aterax
Indication
For symptomatic relief of anxiety and tension associated with psychoneurosis and as an adjunct in organic disease states in which anxiety is manifested. Useful in the management of pruritus due to allergic conditions such as chronic urticaria.
Aterax
Pharmacology
Hydroxyzine, a piperazine antihistamine structurally related to buclizine, cyclizine, and meclizine, is used to treat histamine-mediated pruritus or pruritus due to allergy, nausea and vomiting, and, in combination with an opiate agonist, anxiolytic pain. Hydroxyzine is also used as a perioperative sedative and anxiolytic and to manage acute alcohol withdrawal. Hydroxyzine's active metabolite, cetirizine, is also used as an H1-antagonist.
Aterax
Absorption
Rapidly absorbed from the gastrointestinal tract
Aterax
side effects and Toxicity
Oral, rat LD50: 950 mg/kg. Symptoms of overexposure include hypersedation.
Aterax
Patient Information
Aterax
Organisms Affected
Humans and other mammals