Hychotine
Brand names,
Hychotine
Analogs
Hychotine
Brand Names Mixture
Hychotine
Chemical_Formula
C21H27ClN2O2
Hychotine
RX_link
http://www.rxlist.com/cgi/generic/hydrox.htm
Hychotine
fda sheet
Hychotine
msds (material safety sheet)
Hychotine
Synthesis Reference
Moren; U.S. Pat. 2,899,436 (1959)
Hychotine
Molecular Weight
374.904 g/mol
Hychotine
Melting Point
190 oC
Hychotine
H2O Solubility
< 700 mg/mL
Hychotine
State
Solid
Hychotine
LogP
3.036
Hychotine
Dosage Forms
Capsule; Liquid; Solution; Syrup
Hychotine
Indication
For symptomatic relief of anxiety and tension associated with psychoneurosis and as an adjunct in organic disease states in which anxiety is manifested. Useful in the management of pruritus due to allergic conditions such as chronic urticaria.
Hychotine
Pharmacology
Hydroxyzine, a piperazine antihistamine structurally related to buclizine, cyclizine, and meclizine, is used to treat histamine-mediated pruritus or pruritus due to allergy, nausea and vomiting, and, in combination with an opiate agonist, anxiolytic pain. Hydroxyzine is also used as a perioperative sedative and anxiolytic and to manage acute alcohol withdrawal. Hydroxyzine's active metabolite, cetirizine, is also used as an H1-antagonist.
Hychotine
Absorption
Rapidly absorbed from the gastrointestinal tract
Hychotine
side effects and Toxicity
Oral, rat LD50: 950 mg/kg. Symptoms of overexposure include hypersedation.
Hychotine
Patient Information
Hychotine
Organisms Affected
Humans and other mammals