Atara
Brand names,
Atara
Analogs
Atara
Brand Names Mixture
Atara
Chemical_Formula
C21H27ClN2O2
Atara
RX_link
http://www.rxlist.com/cgi/generic/hydrox.htm
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fda sheet
Atara
msds (material safety sheet)
Atara
Synthesis Reference
Moren; U.S. Pat. 2,899,436 (1959)
Atara
Molecular Weight
374.904 g/mol
Atara
Melting Point
190 oC
Atara
H2O Solubility
< 700 mg/mL
Atara
State
Solid
Atara
LogP
3.036
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Dosage Forms
Capsule; Liquid; Solution; Syrup
Atara
Indication
For symptomatic relief of anxiety and tension associated with psychoneurosis and as an adjunct in organic disease states in which anxiety is manifested. Useful in the management of pruritus due to allergic conditions such as chronic urticaria.
Atara
Pharmacology
Hydroxyzine, a piperazine antihistamine structurally related to buclizine, cyclizine, and meclizine, is used to treat histamine-mediated pruritus or pruritus due to allergy, nausea and vomiting, and, in combination with an opiate agonist, anxiolytic pain. Hydroxyzine is also used as a perioperative sedative and anxiolytic and to manage acute alcohol withdrawal. Hydroxyzine's active metabolite, cetirizine, is also used as an H1-antagonist.
Atara
Absorption
Rapidly absorbed from the gastrointestinal tract
Atara
side effects and Toxicity
Oral, rat LD50: 950 mg/kg. Symptoms of overexposure include hypersedation.
Atara
Patient Information
Atara
Organisms Affected
Humans and other mammals