Neo-Calma
Brand names,
Neo-Calma
Analogs
Neo-Calma
Brand Names Mixture
Neo-Calma
Chemical_Formula
C21H27ClN2O2
Neo-Calma
RX_link
http://www.rxlist.com/cgi/generic/hydrox.htm
Neo-Calma
fda sheet
Neo-Calma
msds (material safety sheet)
Neo-Calma
Synthesis Reference
Moren; U.S. Pat. 2,899,436 (1959)
Neo-Calma
Molecular Weight
374.904 g/mol
Neo-Calma
Melting Point
190 oC
Neo-Calma
H2O Solubility
< 700 mg/mL
Neo-Calma
State
Solid
Neo-Calma
LogP
3.036
Neo-Calma
Dosage Forms
Capsule; Liquid; Solution; Syrup
Neo-Calma
Indication
For symptomatic relief of anxiety and tension associated with psychoneurosis and as an adjunct in organic disease states in which anxiety is manifested. Useful in the management of pruritus due to allergic conditions such as chronic urticaria.
Neo-Calma
Pharmacology
Hydroxyzine, a piperazine antihistamine structurally related to buclizine, cyclizine, and meclizine, is used to treat histamine-mediated pruritus or pruritus due to allergy, nausea and vomiting, and, in combination with an opiate agonist, anxiolytic pain. Hydroxyzine is also used as a perioperative sedative and anxiolytic and to manage acute alcohol withdrawal. Hydroxyzine's active metabolite, cetirizine, is also used as an H1-antagonist.
Neo-Calma
Absorption
Rapidly absorbed from the gastrointestinal tract
Neo-Calma
side effects and Toxicity
Oral, rat LD50: 950 mg/kg. Symptoms of overexposure include hypersedation.
Neo-Calma
Patient Information
Neo-Calma
Organisms Affected
Humans and other mammals