Hydroksyzyny
Brand names,
Hydroksyzyny
Analogs
Hydroksyzyny
Brand Names Mixture
Hydroksyzyny
Chemical_Formula
C21H27ClN2O2
Hydroksyzyny
RX_link
http://www.rxlist.com/cgi/generic/hydrox.htm
Hydroksyzyny
fda sheet
Hydroksyzyny
msds (material safety sheet)
Hydroksyzyny
Synthesis Reference
Moren; U.S. Pat. 2,899,436 (1959)
Hydroksyzyny
Molecular Weight
374.904 g/mol
Hydroksyzyny
Melting Point
190 oC
Hydroksyzyny
H2O Solubility
< 700 mg/mL
Hydroksyzyny
State
Solid
Hydroksyzyny
LogP
3.036
Hydroksyzyny
Dosage Forms
Capsule; Liquid; Solution; Syrup
Hydroksyzyny
Indication
For symptomatic relief of anxiety and tension associated with psychoneurosis and as an adjunct in organic disease states in which anxiety is manifested. Useful in the management of pruritus due to allergic conditions such as chronic urticaria.
Hydroksyzyny
Pharmacology
Hydroxyzine, a piperazine antihistamine structurally related to buclizine, cyclizine, and meclizine, is used to treat histamine-mediated pruritus or pruritus due to allergy, nausea and vomiting, and, in combination with an opiate agonist, anxiolytic pain. Hydroxyzine is also used as a perioperative sedative and anxiolytic and to manage acute alcohol withdrawal. Hydroxyzine's active metabolite, cetirizine, is also used as an H1-antagonist.
Hydroksyzyny
Absorption
Rapidly absorbed from the gastrointestinal tract
Hydroksyzyny
side effects and Toxicity
Oral, rat LD50: 950 mg/kg. Symptoms of overexposure include hypersedation.
Hydroksyzyny
Patient Information
Hydroksyzyny
Organisms Affected
Humans and other mammals