Pamazone
Brand names,
Pamazone
Analogs
Pamazone
Brand Names Mixture
Pamazone
Chemical_Formula
C21H27ClN2O2
Pamazone
RX_link
http://www.rxlist.com/cgi/generic/hydrox.htm
Pamazone
fda sheet
Pamazone
msds (material safety sheet)
Pamazone
Synthesis Reference
Moren; U.S. Pat. 2,899,436 (1959)
Pamazone
Molecular Weight
374.904 g/mol
Pamazone
Melting Point
190 oC
Pamazone
H2O Solubility
< 700 mg/mL
Pamazone
State
Solid
Pamazone
LogP
3.036
Pamazone
Dosage Forms
Capsule; Liquid; Solution; Syrup
Pamazone
Indication
For symptomatic relief of anxiety and tension associated with psychoneurosis and as an adjunct in organic disease states in which anxiety is manifested. Useful in the management of pruritus due to allergic conditions such as chronic urticaria.
Pamazone
Pharmacology
Hydroxyzine, a piperazine antihistamine structurally related to buclizine, cyclizine, and meclizine, is used to treat histamine-mediated pruritus or pruritus due to allergy, nausea and vomiting, and, in combination with an opiate agonist, anxiolytic pain. Hydroxyzine is also used as a perioperative sedative and anxiolytic and to manage acute alcohol withdrawal. Hydroxyzine's active metabolite, cetirizine, is also used as an H1-antagonist.
Pamazone
Absorption
Rapidly absorbed from the gastrointestinal tract
Pamazone
side effects and Toxicity
Oral, rat LD50: 950 mg/kg. Symptoms of overexposure include hypersedation.
Pamazone
Patient Information
Pamazone
Organisms Affected
Humans and other mammals