Paxistil
Brand names,
Paxistil
Analogs
Paxistil
Brand Names Mixture
Paxistil
Chemical_Formula
C21H27ClN2O2
Paxistil
RX_link
http://www.rxlist.com/cgi/generic/hydrox.htm
Paxistil
fda sheet
Paxistil
msds (material safety sheet)
Paxistil
Synthesis Reference
Moren; U.S. Pat. 2,899,436 (1959)
Paxistil
Molecular Weight
374.904 g/mol
Paxistil
Melting Point
190 oC
Paxistil
H2O Solubility
< 700 mg/mL
Paxistil
State
Solid
Paxistil
LogP
3.036
Paxistil
Dosage Forms
Capsule; Liquid; Solution; Syrup
Paxistil
Indication
For symptomatic relief of anxiety and tension associated with psychoneurosis and as an adjunct in organic disease states in which anxiety is manifested. Useful in the management of pruritus due to allergic conditions such as chronic urticaria.
Paxistil
Pharmacology
Hydroxyzine, a piperazine antihistamine structurally related to buclizine, cyclizine, and meclizine, is used to treat histamine-mediated pruritus or pruritus due to allergy, nausea and vomiting, and, in combination with an opiate agonist, anxiolytic pain. Hydroxyzine is also used as a perioperative sedative and anxiolytic and to manage acute alcohol withdrawal. Hydroxyzine's active metabolite, cetirizine, is also used as an H1-antagonist.
Paxistil
Absorption
Rapidly absorbed from the gastrointestinal tract
Paxistil
side effects and Toxicity
Oral, rat LD50: 950 mg/kg. Symptoms of overexposure include hypersedation.
Paxistil
Patient Information
Paxistil
Organisms Affected
Humans and other mammals