Placidol
Brand names,
Placidol
Analogs
Placidol
Brand Names Mixture
Placidol
Chemical_Formula
C21H27ClN2O2
Placidol
RX_link
http://www.rxlist.com/cgi/generic/hydrox.htm
Placidol
fda sheet
Placidol
msds (material safety sheet)
Placidol
Synthesis Reference
Moren; U.S. Pat. 2,899,436 (1959)
Placidol
Molecular Weight
374.904 g/mol
Placidol
Melting Point
190 oC
Placidol
H2O Solubility
< 700 mg/mL
Placidol
State
Solid
Placidol
LogP
3.036
Placidol
Dosage Forms
Capsule; Liquid; Solution; Syrup
Placidol
Indication
For symptomatic relief of anxiety and tension associated with psychoneurosis and as an adjunct in organic disease states in which anxiety is manifested. Useful in the management of pruritus due to allergic conditions such as chronic urticaria.
Placidol
Pharmacology
Hydroxyzine, a piperazine antihistamine structurally related to buclizine, cyclizine, and meclizine, is used to treat histamine-mediated pruritus or pruritus due to allergy, nausea and vomiting, and, in combination with an opiate agonist, anxiolytic pain. Hydroxyzine is also used as a perioperative sedative and anxiolytic and to manage acute alcohol withdrawal. Hydroxyzine's active metabolite, cetirizine, is also used as an H1-antagonist.
Placidol
Absorption
Rapidly absorbed from the gastrointestinal tract
Placidol
side effects and Toxicity
Oral, rat LD50: 950 mg/kg. Symptoms of overexposure include hypersedation.
Placidol
Patient Information
Placidol
Organisms Affected
Humans and other mammals