Idrossizina
Brand names,
Idrossizina
Analogs
Idrossizina
Brand Names Mixture
Idrossizina
Chemical_Formula
C21H27ClN2O2
Idrossizina
RX_link
http://www.rxlist.com/cgi/generic/hydrox.htm
Idrossizina
fda sheet
Idrossizina
msds (material safety sheet)
Idrossizina
Synthesis Reference
Moren; U.S. Pat. 2,899,436 (1959)
Idrossizina
Molecular Weight
374.904 g/mol
Idrossizina
Melting Point
190 oC
Idrossizina
H2O Solubility
< 700 mg/mL
Idrossizina
State
Solid
Idrossizina
LogP
3.036
Idrossizina
Dosage Forms
Capsule; Liquid; Solution; Syrup
Idrossizina
Indication
For symptomatic relief of anxiety and tension associated with psychoneurosis and as an adjunct in organic disease states in which anxiety is manifested. Useful in the management of pruritus due to allergic conditions such as chronic urticaria.
Idrossizina
Pharmacology
Hydroxyzine, a piperazine antihistamine structurally related to buclizine, cyclizine, and meclizine, is used to treat histamine-mediated pruritus or pruritus due to allergy, nausea and vomiting, and, in combination with an opiate agonist, anxiolytic pain. Hydroxyzine is also used as a perioperative sedative and anxiolytic and to manage acute alcohol withdrawal. Hydroxyzine's active metabolite, cetirizine, is also used as an H1-antagonist.
Idrossizina
Absorption
Rapidly absorbed from the gastrointestinal tract
Idrossizina
side effects and Toxicity
Oral, rat LD50: 950 mg/kg. Symptoms of overexposure include hypersedation.
Idrossizina
Patient Information
Idrossizina
Organisms Affected
Humans and other mammals