Equipose
Brand names,
Equipose
Analogs
Equipose
Brand Names Mixture
Equipose
Chemical_Formula
C21H27ClN2O2
Equipose
RX_link
http://www.rxlist.com/cgi/generic/hydrox.htm
Equipose
fda sheet
Equipose
msds (material safety sheet)
Equipose
Synthesis Reference
Moren; U.S. Pat. 2,899,436 (1959)
Equipose
Molecular Weight
374.904 g/mol
Equipose
Melting Point
190 oC
Equipose
H2O Solubility
< 700 mg/mL
Equipose
State
Solid
Equipose
LogP
3.036
Equipose
Dosage Forms
Capsule; Liquid; Solution; Syrup
Equipose
Indication
For symptomatic relief of anxiety and tension associated with psychoneurosis and as an adjunct in organic disease states in which anxiety is manifested. Useful in the management of pruritus due to allergic conditions such as chronic urticaria.
Equipose
Pharmacology
Hydroxyzine, a piperazine antihistamine structurally related to buclizine, cyclizine, and meclizine, is used to treat histamine-mediated pruritus or pruritus due to allergy, nausea and vomiting, and, in combination with an opiate agonist, anxiolytic pain. Hydroxyzine is also used as a perioperative sedative and anxiolytic and to manage acute alcohol withdrawal. Hydroxyzine's active metabolite, cetirizine, is also used as an H1-antagonist.
Equipose
Absorption
Rapidly absorbed from the gastrointestinal tract
Equipose
side effects and Toxicity
Oral, rat LD50: 950 mg/kg. Symptoms of overexposure include hypersedation.
Equipose
Patient Information
Equipose
Organisms Affected
Humans and other mammals