Hydroxyzyne
Brand names,
Hydroxyzyne
Analogs
Hydroxyzyne
Brand Names Mixture
Hydroxyzyne
Chemical_Formula
C21H27ClN2O2
Hydroxyzyne
RX_link
http://www.rxlist.com/cgi/generic/hydrox.htm
Hydroxyzyne
fda sheet
Hydroxyzyne
msds (material safety sheet)
Hydroxyzyne
Synthesis Reference
Moren; U.S. Pat. 2,899,436 (1959)
Hydroxyzyne
Molecular Weight
374.904 g/mol
Hydroxyzyne
Melting Point
190 oC
Hydroxyzyne
H2O Solubility
< 700 mg/mL
Hydroxyzyne
State
Solid
Hydroxyzyne
LogP
3.036
Hydroxyzyne
Dosage Forms
Capsule; Liquid; Solution; Syrup
Hydroxyzyne
Indication
For symptomatic relief of anxiety and tension associated with psychoneurosis and as an adjunct in organic disease states in which anxiety is manifested. Useful in the management of pruritus due to allergic conditions such as chronic urticaria.
Hydroxyzyne
Pharmacology
Hydroxyzine, a piperazine antihistamine structurally related to buclizine, cyclizine, and meclizine, is used to treat histamine-mediated pruritus or pruritus due to allergy, nausea and vomiting, and, in combination with an opiate agonist, anxiolytic pain. Hydroxyzine is also used as a perioperative sedative and anxiolytic and to manage acute alcohol withdrawal. Hydroxyzine's active metabolite, cetirizine, is also used as an H1-antagonist.
Hydroxyzyne
Absorption
Rapidly absorbed from the gastrointestinal tract
Hydroxyzyne
side effects and Toxicity
Oral, rat LD50: 950 mg/kg. Symptoms of overexposure include hypersedation.
Hydroxyzyne
Patient Information
Hydroxyzyne
Organisms Affected
Humans and other mammals