Atarox
Brand names,
Atarox
Analogs
Atarox
Brand Names Mixture
Atarox
Chemical_Formula
C21H27ClN2O2
Atarox
RX_link
http://www.rxlist.com/cgi/generic/hydrox.htm
Atarox
fda sheet
Atarox
msds (material safety sheet)
Atarox
Synthesis Reference
Moren; U.S. Pat. 2,899,436 (1959)
Atarox
Molecular Weight
374.904 g/mol
Atarox
Melting Point
190 oC
Atarox
H2O Solubility
< 700 mg/mL
Atarox
State
Solid
Atarox
LogP
3.036
Atarox
Dosage Forms
Capsule; Liquid; Solution; Syrup
Atarox
Indication
For symptomatic relief of anxiety and tension associated with psychoneurosis and as an adjunct in organic disease states in which anxiety is manifested. Useful in the management of pruritus due to allergic conditions such as chronic urticaria.
Atarox
Pharmacology
Hydroxyzine, a piperazine antihistamine structurally related to buclizine, cyclizine, and meclizine, is used to treat histamine-mediated pruritus or pruritus due to allergy, nausea and vomiting, and, in combination with an opiate agonist, anxiolytic pain. Hydroxyzine is also used as a perioperative sedative and anxiolytic and to manage acute alcohol withdrawal. Hydroxyzine's active metabolite, cetirizine, is also used as an H1-antagonist.
Atarox
Absorption
Rapidly absorbed from the gastrointestinal tract
Atarox
side effects and Toxicity
Oral, rat LD50: 950 mg/kg. Symptoms of overexposure include hypersedation.
Atarox
Patient Information
Atarox
Organisms Affected
Humans and other mammals