Tranquizine
Brand names,
Tranquizine
Analogs
Tranquizine
Brand Names Mixture
Tranquizine
Chemical_Formula
C21H27ClN2O2
Tranquizine
RX_link
http://www.rxlist.com/cgi/generic/hydrox.htm
Tranquizine
fda sheet
Tranquizine
msds (material safety sheet)
Tranquizine
Synthesis Reference
Moren; U.S. Pat. 2,899,436 (1959)
Tranquizine
Molecular Weight
374.904 g/mol
Tranquizine
Melting Point
190 oC
Tranquizine
H2O Solubility
< 700 mg/mL
Tranquizine
State
Solid
Tranquizine
LogP
3.036
Tranquizine
Dosage Forms
Capsule; Liquid; Solution; Syrup
Tranquizine
Indication
For symptomatic relief of anxiety and tension associated with psychoneurosis and as an adjunct in organic disease states in which anxiety is manifested. Useful in the management of pruritus due to allergic conditions such as chronic urticaria.
Tranquizine
Pharmacology
Hydroxyzine, a piperazine antihistamine structurally related to buclizine, cyclizine, and meclizine, is used to treat histamine-mediated pruritus or pruritus due to allergy, nausea and vomiting, and, in combination with an opiate agonist, anxiolytic pain. Hydroxyzine is also used as a perioperative sedative and anxiolytic and to manage acute alcohol withdrawal. Hydroxyzine's active metabolite, cetirizine, is also used as an H1-antagonist.
Tranquizine
Absorption
Rapidly absorbed from the gastrointestinal tract
Tranquizine
side effects and Toxicity
Oral, rat LD50: 950 mg/kg. Symptoms of overexposure include hypersedation.
Tranquizine
Patient Information
Tranquizine
Organisms Affected
Humans and other mammals