Hydroxyzine Pamoate
Brand names,
Hydroxyzine Pamoate
Analogs
Hydroxyzine Pamoate
Brand Names Mixture
Hydroxyzine Pamoate
Chemical_Formula
C21H27ClN2O2
Hydroxyzine Pamoate
RX_link
http://www.rxlist.com/cgi/generic/hydrox.htm
Hydroxyzine Pamoate
fda sheet
Hydroxyzine Pamoate
msds (material safety sheet)
Hydroxyzine Pamoate
Synthesis Reference
Moren; U.S. Pat. 2,899,436 (1959)
Hydroxyzine Pamoate
Molecular Weight
374.904 g/mol
Hydroxyzine Pamoate
Melting Point
190 oC
Hydroxyzine Pamoate
H2O Solubility
< 700 mg/mL
Hydroxyzine Pamoate
State
Solid
Hydroxyzine Pamoate
LogP
3.036
Hydroxyzine Pamoate
Dosage Forms
Capsule; Liquid; Solution; Syrup
Hydroxyzine Pamoate
Indication
For symptomatic relief of anxiety and tension associated with psychoneurosis and as an adjunct in organic disease states in which anxiety is manifested. Useful in the management of pruritus due to allergic conditions such as chronic urticaria.
Hydroxyzine Pamoate
Pharmacology
Hydroxyzine, a piperazine antihistamine structurally related to buclizine, cyclizine, and meclizine, is used to treat histamine-mediated pruritus or pruritus due to allergy, nausea and vomiting, and, in combination with an opiate agonist, anxiolytic pain. Hydroxyzine is also used as a perioperative sedative and anxiolytic and to manage acute alcohol withdrawal. Hydroxyzine's active metabolite, cetirizine, is also used as an H1-antagonist.
Hydroxyzine Pamoate
Absorption
Rapidly absorbed from the gastrointestinal tract
Hydroxyzine Pamoate
side effects and Toxicity
Oral, rat LD50: 950 mg/kg. Symptoms of overexposure include hypersedation.
Hydroxyzine Pamoate
Patient Information
Hydroxyzine Pamoate
Organisms Affected
Humans and other mammals