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Brand names,
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Analogs
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Brand Names Mixture
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Chemical_Formula
C21H27ClN2O2
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RX_link
http://www.rxlist.com/cgi/generic/hydrox.htm
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
Moren; U.S. Pat. 2,899,436 (1959)
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Molecular Weight
374.904 g/mol
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Melting Point
190 oC
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H2O Solubility
< 700 mg/mL
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State
Solid
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LogP
3.036
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Dosage Forms
Capsule; Liquid; Solution; Syrup
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Indication
For symptomatic relief of anxiety and tension associated with psychoneurosis and as an adjunct in organic disease states in which anxiety is manifested. Useful in the management of pruritus due to allergic conditions such as chronic urticaria.
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Pharmacology
Hydroxyzine, a piperazine antihistamine structurally related to buclizine, cyclizine, and meclizine, is used to treat histamine-mediated pruritus or pruritus due to allergy, nausea and vomiting, and, in combination with an opiate agonist, anxiolytic pain. Hydroxyzine is also used as a perioperative sedative and anxiolytic and to manage acute alcohol withdrawal. Hydroxyzine's active metabolite, cetirizine, is also used as an H1-antagonist.
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Absorption
Rapidly absorbed from the gastrointestinal tract
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side effects and Toxicity
Oral, rat LD50: 950 mg/kg. Symptoms of overexposure include hypersedation.
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Patient Information
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Organisms Affected
Humans and other mammals