Atazina
Brand names,
Atazina
Analogs
Atazina
Brand Names Mixture
Atazina
Chemical_Formula
C21H27ClN2O2
Atazina
RX_link
http://www.rxlist.com/cgi/generic/hydrox.htm
Atazina
fda sheet
Atazina
msds (material safety sheet)
Atazina
Synthesis Reference
Moren; U.S. Pat. 2,899,436 (1959)
Atazina
Molecular Weight
374.904 g/mol
Atazina
Melting Point
190 oC
Atazina
H2O Solubility
< 700 mg/mL
Atazina
State
Solid
Atazina
LogP
3.036
Atazina
Dosage Forms
Capsule; Liquid; Solution; Syrup
Atazina
Indication
For symptomatic relief of anxiety and tension associated with psychoneurosis and as an adjunct in organic disease states in which anxiety is manifested. Useful in the management of pruritus due to allergic conditions such as chronic urticaria.
Atazina
Pharmacology
Hydroxyzine, a piperazine antihistamine structurally related to buclizine, cyclizine, and meclizine, is used to treat histamine-mediated pruritus or pruritus due to allergy, nausea and vomiting, and, in combination with an opiate agonist, anxiolytic pain. Hydroxyzine is also used as a perioperative sedative and anxiolytic and to manage acute alcohol withdrawal. Hydroxyzine's active metabolite, cetirizine, is also used as an H1-antagonist.
Atazina
Absorption
Rapidly absorbed from the gastrointestinal tract
Atazina
side effects and Toxicity
Oral, rat LD50: 950 mg/kg. Symptoms of overexposure include hypersedation.
Atazina
Patient Information
Atazina
Organisms Affected
Humans and other mammals