Hydroxizinum
Brand names,
Hydroxizinum
Analogs
Hydroxizinum
Brand Names Mixture
Hydroxizinum
Chemical_Formula
C21H27ClN2O2
Hydroxizinum
RX_link
http://www.rxlist.com/cgi/generic/hydrox.htm
Hydroxizinum
fda sheet
Hydroxizinum
msds (material safety sheet)
Hydroxizinum
Synthesis Reference
Moren; U.S. Pat. 2,899,436 (1959)
Hydroxizinum
Molecular Weight
374.904 g/mol
Hydroxizinum
Melting Point
190 oC
Hydroxizinum
H2O Solubility
< 700 mg/mL
Hydroxizinum
State
Solid
Hydroxizinum
LogP
3.036
Hydroxizinum
Dosage Forms
Capsule; Liquid; Solution; Syrup
Hydroxizinum
Indication
For symptomatic relief of anxiety and tension associated with psychoneurosis and as an adjunct in organic disease states in which anxiety is manifested. Useful in the management of pruritus due to allergic conditions such as chronic urticaria.
Hydroxizinum
Pharmacology
Hydroxyzine, a piperazine antihistamine structurally related to buclizine, cyclizine, and meclizine, is used to treat histamine-mediated pruritus or pruritus due to allergy, nausea and vomiting, and, in combination with an opiate agonist, anxiolytic pain. Hydroxyzine is also used as a perioperative sedative and anxiolytic and to manage acute alcohol withdrawal. Hydroxyzine's active metabolite, cetirizine, is also used as an H1-antagonist.
Hydroxizinum
Absorption
Rapidly absorbed from the gastrointestinal tract
Hydroxizinum
side effects and Toxicity
Oral, rat LD50: 950 mg/kg. Symptoms of overexposure include hypersedation.
Hydroxizinum
Patient Information
Hydroxizinum
Organisms Affected
Humans and other mammals