Ataraxoid
Brand names,
Ataraxoid
Analogs
Ataraxoid
Brand Names Mixture
Ataraxoid
Chemical_Formula
C21H27ClN2O2
Ataraxoid
RX_link
http://www.rxlist.com/cgi/generic/hydrox.htm
Ataraxoid
fda sheet
Ataraxoid
msds (material safety sheet)
Ataraxoid
Synthesis Reference
Moren; U.S. Pat. 2,899,436 (1959)
Ataraxoid
Molecular Weight
374.904 g/mol
Ataraxoid
Melting Point
190 oC
Ataraxoid
H2O Solubility
< 700 mg/mL
Ataraxoid
State
Solid
Ataraxoid
LogP
3.036
Ataraxoid
Dosage Forms
Capsule; Liquid; Solution; Syrup
Ataraxoid
Indication
For symptomatic relief of anxiety and tension associated with psychoneurosis and as an adjunct in organic disease states in which anxiety is manifested. Useful in the management of pruritus due to allergic conditions such as chronic urticaria.
Ataraxoid
Pharmacology
Hydroxyzine, a piperazine antihistamine structurally related to buclizine, cyclizine, and meclizine, is used to treat histamine-mediated pruritus or pruritus due to allergy, nausea and vomiting, and, in combination with an opiate agonist, anxiolytic pain. Hydroxyzine is also used as a perioperative sedative and anxiolytic and to manage acute alcohol withdrawal. Hydroxyzine's active metabolite, cetirizine, is also used as an H1-antagonist.
Ataraxoid
Absorption
Rapidly absorbed from the gastrointestinal tract
Ataraxoid
side effects and Toxicity
Oral, rat LD50: 950 mg/kg. Symptoms of overexposure include hypersedation.
Ataraxoid
Patient Information
Ataraxoid
Organisms Affected
Humans and other mammals