Hydroxycine
Brand names,
Hydroxycine
Analogs
Hydroxycine
Brand Names Mixture
Hydroxycine
Chemical_Formula
C21H27ClN2O2
Hydroxycine
RX_link
http://www.rxlist.com/cgi/generic/hydrox.htm
Hydroxycine
fda sheet
Hydroxycine
msds (material safety sheet)
Hydroxycine
Synthesis Reference
Moren; U.S. Pat. 2,899,436 (1959)
Hydroxycine
Molecular Weight
374.904 g/mol
Hydroxycine
Melting Point
190 oC
Hydroxycine
H2O Solubility
< 700 mg/mL
Hydroxycine
State
Solid
Hydroxycine
LogP
3.036
Hydroxycine
Dosage Forms
Capsule; Liquid; Solution; Syrup
Hydroxycine
Indication
For symptomatic relief of anxiety and tension associated with psychoneurosis and as an adjunct in organic disease states in which anxiety is manifested. Useful in the management of pruritus due to allergic conditions such as chronic urticaria.
Hydroxycine
Pharmacology
Hydroxyzine, a piperazine antihistamine structurally related to buclizine, cyclizine, and meclizine, is used to treat histamine-mediated pruritus or pruritus due to allergy, nausea and vomiting, and, in combination with an opiate agonist, anxiolytic pain. Hydroxyzine is also used as a perioperative sedative and anxiolytic and to manage acute alcohol withdrawal. Hydroxyzine's active metabolite, cetirizine, is also used as an H1-antagonist.
Hydroxycine
Absorption
Rapidly absorbed from the gastrointestinal tract
Hydroxycine
side effects and Toxicity
Oral, rat LD50: 950 mg/kg. Symptoms of overexposure include hypersedation.
Hydroxycine
Patient Information
Hydroxycine
Organisms Affected
Humans and other mammals