Hydroxyzine Hcl
Brand names,
Hydroxyzine Hcl
Analogs
Hydroxyzine Hcl
Brand Names Mixture
Hydroxyzine Hcl
Chemical_Formula
C21H27ClN2O2
Hydroxyzine Hcl
RX_link
http://www.rxlist.com/cgi/generic/hydrox.htm
Hydroxyzine Hcl
fda sheet
Hydroxyzine Hcl
msds (material safety sheet)
Hydroxyzine Hcl
Synthesis Reference
Moren; U.S. Pat. 2,899,436 (1959)
Hydroxyzine Hcl
Molecular Weight
374.904 g/mol
Hydroxyzine Hcl
Melting Point
190 oC
Hydroxyzine Hcl
H2O Solubility
< 700 mg/mL
Hydroxyzine Hcl
State
Solid
Hydroxyzine Hcl
LogP
3.036
Hydroxyzine Hcl
Dosage Forms
Capsule; Liquid; Solution; Syrup
Hydroxyzine Hcl
Indication
For symptomatic relief of anxiety and tension associated with psychoneurosis and as an adjunct in organic disease states in which anxiety is manifested. Useful in the management of pruritus due to allergic conditions such as chronic urticaria.
Hydroxyzine Hcl
Pharmacology
Hydroxyzine, a piperazine antihistamine structurally related to buclizine, cyclizine, and meclizine, is used to treat histamine-mediated pruritus or pruritus due to allergy, nausea and vomiting, and, in combination with an opiate agonist, anxiolytic pain. Hydroxyzine is also used as a perioperative sedative and anxiolytic and to manage acute alcohol withdrawal. Hydroxyzine's active metabolite, cetirizine, is also used as an H1-antagonist.
Hydroxyzine Hcl
Absorption
Rapidly absorbed from the gastrointestinal tract
Hydroxyzine Hcl
side effects and Toxicity
Oral, rat LD50: 950 mg/kg. Symptoms of overexposure include hypersedation.
Hydroxyzine Hcl
Patient Information
Hydroxyzine Hcl
Organisms Affected
Humans and other mammals