Durrax
Brand names,
Durrax
Analogs
Durrax
Brand Names Mixture
Durrax
Chemical_Formula
C21H27ClN2O2
Durrax
RX_link
http://www.rxlist.com/cgi/generic/hydrox.htm
Durrax
fda sheet
Durrax
msds (material safety sheet)
Durrax
Synthesis Reference
Moren; U.S. Pat. 2,899,436 (1959)
Durrax
Molecular Weight
374.904 g/mol
Durrax
Melting Point
190 oC
Durrax
H2O Solubility
< 700 mg/mL
Durrax
State
Solid
Durrax
LogP
3.036
Durrax
Dosage Forms
Capsule; Liquid; Solution; Syrup
Durrax
Indication
For symptomatic relief of anxiety and tension associated with psychoneurosis and as an adjunct in organic disease states in which anxiety is manifested. Useful in the management of pruritus due to allergic conditions such as chronic urticaria.
Durrax
Pharmacology
Hydroxyzine, a piperazine antihistamine structurally related to buclizine, cyclizine, and meclizine, is used to treat histamine-mediated pruritus or pruritus due to allergy, nausea and vomiting, and, in combination with an opiate agonist, anxiolytic pain. Hydroxyzine is also used as a perioperative sedative and anxiolytic and to manage acute alcohol withdrawal. Hydroxyzine's active metabolite, cetirizine, is also used as an H1-antagonist.
Durrax
Absorption
Rapidly absorbed from the gastrointestinal tract
Durrax
side effects and Toxicity
Oral, rat LD50: 950 mg/kg. Symptoms of overexposure include hypersedation.
Durrax
Patient Information
Durrax
Organisms Affected
Humans and other mammals