Orgatrax
Brand names,
Orgatrax
Analogs
Orgatrax
Brand Names Mixture
Orgatrax
Chemical_Formula
C21H27ClN2O2
Orgatrax
RX_link
http://www.rxlist.com/cgi/generic/hydrox.htm
Orgatrax
fda sheet
Orgatrax
msds (material safety sheet)
Orgatrax
Synthesis Reference
Moren; U.S. Pat. 2,899,436 (1959)
Orgatrax
Molecular Weight
374.904 g/mol
Orgatrax
Melting Point
190 oC
Orgatrax
H2O Solubility
< 700 mg/mL
Orgatrax
State
Solid
Orgatrax
LogP
3.036
Orgatrax
Dosage Forms
Capsule; Liquid; Solution; Syrup
Orgatrax
Indication
For symptomatic relief of anxiety and tension associated with psychoneurosis and as an adjunct in organic disease states in which anxiety is manifested. Useful in the management of pruritus due to allergic conditions such as chronic urticaria.
Orgatrax
Pharmacology
Hydroxyzine, a piperazine antihistamine structurally related to buclizine, cyclizine, and meclizine, is used to treat histamine-mediated pruritus or pruritus due to allergy, nausea and vomiting, and, in combination with an opiate agonist, anxiolytic pain. Hydroxyzine is also used as a perioperative sedative and anxiolytic and to manage acute alcohol withdrawal. Hydroxyzine's active metabolite, cetirizine, is also used as an H1-antagonist.
Orgatrax
Absorption
Rapidly absorbed from the gastrointestinal tract
Orgatrax
side effects and Toxicity
Oral, rat LD50: 950 mg/kg. Symptoms of overexposure include hypersedation.
Orgatrax
Patient Information
Orgatrax
Organisms Affected
Humans and other mammals