Pyoktanin
Brand names,
Pyoktanin
Analogs
Pyoktanin
Brand Names Mixture
Pyoktanin
Chemical_Formula
C25H30N3+
Pyoktanin
RX_link
No information avaliable
Pyoktanin
fda sheet
Pyoktanin
msds (material safety sheet)
Pyoktanin
Synthesis Reference
No information avaliable
Pyoktanin
Molecular Weight
372.526 g/mol
Pyoktanin
Melting Point
215 oC
Pyoktanin
H2O Solubility
4 mg/mL
Pyoktanin
State
Solid
Pyoktanin
LogP
3.18
Pyoktanin
Dosage Forms
Liquid; Tincture
Pyoktanin
Indication
For the treatment of bacterial and fungal infections inside the mouth (thrush) and skin, also for the prevention of transmission of Chagas' disease (as a blood additive).
Pyoktanin
Pharmacology
Gentian violet is a mutagen, a mitotic poison, and a clastogen. Gentian violet has been used in medicine for almost 100 years: as an antiseptic for external use, as a topical antibiotic, as a topical antifungal agent, as an antihelminthic agent by oral administration, and more recently, as a blood additive to prevent transmission of Chagas' disease. It is thought to work by binding to the DNA of target organisms and causing disruption, mutation or inhibition of DNA replication.
Pyoktanin
Absorption
No information avaliable
Pyoktanin
side effects and Toxicity
LD50=420 mg/kg (rat, oral). Oral administration can cause gastrointestinal irritation, and intravenous injection can cause depression in the white blood cell count.
Pyoktanin
Patient Information
Pyoktanin
Organisms Affected
Yeast and other fungi, bacteria and protozoans