Gvs
Brand names,
Gvs
Analogs
Gvs
Brand Names Mixture
Gvs
Chemical_Formula
C25H30N3+
Gvs
RX_link
No information avaliable
Gvs
fda sheet
Gvs
msds (material safety sheet)
Gvs
Synthesis Reference
No information avaliable
Gvs
Molecular Weight
372.526 g/mol
Gvs
Melting Point
215 oC
Gvs
H2O Solubility
4 mg/mL
Gvs
State
Solid
Gvs
LogP
3.18
Gvs
Dosage Forms
Liquid; Tincture
Gvs
Indication
For the treatment of bacterial and fungal infections inside the mouth (thrush) and skin, also for the prevention of transmission of Chagas' disease (as a blood additive).
Gvs
Pharmacology
Gentian violet is a mutagen, a mitotic poison, and a clastogen. Gentian violet has been used in medicine for almost 100 years: as an antiseptic for external use, as a topical antibiotic, as a topical antifungal agent, as an antihelminthic agent by oral administration, and more recently, as a blood additive to prevent transmission of Chagas' disease. It is thought to work by binding to the DNA of target organisms and causing disruption, mutation or inhibition of DNA replication.
Gvs
Absorption
No information avaliable
Gvs
side effects and Toxicity
LD50=420 mg/kg (rat, oral). Oral administration can cause gastrointestinal irritation, and intravenous injection can cause depression in the white blood cell count.
Gvs
Patient Information
Gvs
Organisms Affected
Yeast and other fungi, bacteria and protozoans