Violet XXIII
Brand names,
Violet XXIII
Analogs
Violet XXIII
Brand Names Mixture
Violet XXIII
Chemical_Formula
C25H30N3+
Violet XXIII
RX_link
No information avaliable
Violet XXIII
fda sheet
Violet XXIII
msds (material safety sheet)
Violet XXIII
Synthesis Reference
No information avaliable
Violet XXIII
Molecular Weight
372.526 g/mol
Violet XXIII
Melting Point
215 oC
Violet XXIII
H2O Solubility
4 mg/mL
Violet XXIII
State
Solid
Violet XXIII
LogP
3.18
Violet XXIII
Dosage Forms
Liquid; Tincture
Violet XXIII
Indication
For the treatment of bacterial and fungal infections inside the mouth (thrush) and skin, also for the prevention of transmission of Chagas' disease (as a blood additive).
Violet XXIII
Pharmacology
Gentian violet is a mutagen, a mitotic poison, and a clastogen. Gentian violet has been used in medicine for almost 100 years: as an antiseptic for external use, as a topical antibiotic, as a topical antifungal agent, as an antihelminthic agent by oral administration, and more recently, as a blood additive to prevent transmission of Chagas' disease. It is thought to work by binding to the DNA of target organisms and causing disruption, mutation or inhibition of DNA replication.
Violet XXIII
Absorption
No information avaliable
Violet XXIII
side effects and Toxicity
LD50=420 mg/kg (rat, oral). Oral administration can cause gastrointestinal irritation, and intravenous injection can cause depression in the white blood cell count.
Violet XXIII
Patient Information
Violet XXIII
Organisms Affected
Yeast and other fungi, bacteria and protozoans