GV-Eleven
Brand names,
GV-Eleven
Analogs
GV-Eleven
Brand Names Mixture
GV-Eleven
Chemical_Formula
C25H30N3+
GV-Eleven
RX_link
No information avaliable
GV-Eleven
fda sheet
GV-Eleven
msds (material safety sheet)
GV-Eleven
Synthesis Reference
No information avaliable
GV-Eleven
Molecular Weight
372.526 g/mol
GV-Eleven
Melting Point
215 oC
GV-Eleven
H2O Solubility
4 mg/mL
GV-Eleven
State
Solid
GV-Eleven
LogP
3.18
GV-Eleven
Dosage Forms
Liquid; Tincture
GV-Eleven
Indication
For the treatment of bacterial and fungal infections inside the mouth (thrush) and skin, also for the prevention of transmission of Chagas' disease (as a blood additive).
GV-Eleven
Pharmacology
Gentian violet is a mutagen, a mitotic poison, and a clastogen. Gentian violet has been used in medicine for almost 100 years: as an antiseptic for external use, as a topical antibiotic, as a topical antifungal agent, as an antihelminthic agent by oral administration, and more recently, as a blood additive to prevent transmission of Chagas' disease. It is thought to work by binding to the DNA of target organisms and causing disruption, mutation or inhibition of DNA replication.
GV-Eleven
Absorption
No information avaliable
GV-Eleven
side effects and Toxicity
LD50=420 mg/kg (rat, oral). Oral administration can cause gastrointestinal irritation, and intravenous injection can cause depression in the white blood cell count.
GV-Eleven
Patient Information
GV-Eleven
Organisms Affected
Yeast and other fungi, bacteria and protozoans