Gentioletten
Brand names,
Gentioletten
Analogs
Gentioletten
Brand Names Mixture
Gentioletten
Chemical_Formula
C25H30N3+
Gentioletten
RX_link
No information avaliable
Gentioletten
fda sheet
Gentioletten
msds (material safety sheet)
Gentioletten
Synthesis Reference
No information avaliable
Gentioletten
Molecular Weight
372.526 g/mol
Gentioletten
Melting Point
215 oC
Gentioletten
H2O Solubility
4 mg/mL
Gentioletten
State
Solid
Gentioletten
LogP
3.18
Gentioletten
Dosage Forms
Liquid; Tincture
Gentioletten
Indication
For the treatment of bacterial and fungal infections inside the mouth (thrush) and skin, also for the prevention of transmission of Chagas' disease (as a blood additive).
Gentioletten
Pharmacology
Gentian violet is a mutagen, a mitotic poison, and a clastogen. Gentian violet has been used in medicine for almost 100 years: as an antiseptic for external use, as a topical antibiotic, as a topical antifungal agent, as an antihelminthic agent by oral administration, and more recently, as a blood additive to prevent transmission of Chagas' disease. It is thought to work by binding to the DNA of target organisms and causing disruption, mutation or inhibition of DNA replication.
Gentioletten
Absorption
No information avaliable
Gentioletten
side effects and Toxicity
LD50=420 mg/kg (rat, oral). Oral administration can cause gastrointestinal irritation, and intravenous injection can cause depression in the white blood cell count.
Gentioletten
Patient Information
Gentioletten
Organisms Affected
Yeast and other fungi, bacteria and protozoans