Gentersal
Brand names,
Gentersal
Analogs
Gentersal
Brand Names Mixture
Gentersal
Chemical_Formula
C25H30N3+
Gentersal
RX_link
No information avaliable
Gentersal
fda sheet
Gentersal
msds (material safety sheet)
Gentersal
Synthesis Reference
No information avaliable
Gentersal
Molecular Weight
372.526 g/mol
Gentersal
Melting Point
215 oC
Gentersal
H2O Solubility
4 mg/mL
Gentersal
State
Solid
Gentersal
LogP
3.18
Gentersal
Dosage Forms
Liquid; Tincture
Gentersal
Indication
For the treatment of bacterial and fungal infections inside the mouth (thrush) and skin, also for the prevention of transmission of Chagas' disease (as a blood additive).
Gentersal
Pharmacology
Gentian violet is a mutagen, a mitotic poison, and a clastogen. Gentian violet has been used in medicine for almost 100 years: as an antiseptic for external use, as a topical antibiotic, as a topical antifungal agent, as an antihelminthic agent by oral administration, and more recently, as a blood additive to prevent transmission of Chagas' disease. It is thought to work by binding to the DNA of target organisms and causing disruption, mutation or inhibition of DNA replication.
Gentersal
Absorption
No information avaliable
Gentersal
side effects and Toxicity
LD50=420 mg/kg (rat, oral). Oral administration can cause gastrointestinal irritation, and intravenous injection can cause depression in the white blood cell count.
Gentersal
Patient Information
Gentersal
Organisms Affected
Yeast and other fungi, bacteria and protozoans