Adergon
Brand names,
Adergon
Analogs
Adergon
Brand Names Mixture
Adergon
Chemical_Formula
C25H30N3+
Adergon
RX_link
No information avaliable
Adergon
fda sheet
Adergon
msds (material safety sheet)
Adergon
Synthesis Reference
No information avaliable
Adergon
Molecular Weight
372.526 g/mol
Adergon
Melting Point
215 oC
Adergon
H2O Solubility
4 mg/mL
Adergon
State
Solid
Adergon
LogP
3.18
Adergon
Dosage Forms
Liquid; Tincture
Adergon
Indication
For the treatment of bacterial and fungal infections inside the mouth (thrush) and skin, also for the prevention of transmission of Chagas' disease (as a blood additive).
Adergon
Pharmacology
Gentian violet is a mutagen, a mitotic poison, and a clastogen. Gentian violet has been used in medicine for almost 100 years: as an antiseptic for external use, as a topical antibiotic, as a topical antifungal agent, as an antihelminthic agent by oral administration, and more recently, as a blood additive to prevent transmission of Chagas' disease. It is thought to work by binding to the DNA of target organisms and causing disruption, mutation or inhibition of DNA replication.
Adergon
Absorption
No information avaliable
Adergon
side effects and Toxicity
LD50=420 mg/kg (rat, oral). Oral administration can cause gastrointestinal irritation, and intravenous injection can cause depression in the white blood cell count.
Adergon
Patient Information
Adergon
Organisms Affected
Yeast and other fungi, bacteria and protozoans