Gentiaverm
Brand names,
Gentiaverm
Analogs
Gentiaverm
Brand Names Mixture
Gentiaverm
Chemical_Formula
C25H30N3+
Gentiaverm
RX_link
No information avaliable
Gentiaverm
fda sheet
Gentiaverm
msds (material safety sheet)
Gentiaverm
Synthesis Reference
No information avaliable
Gentiaverm
Molecular Weight
372.526 g/mol
Gentiaverm
Melting Point
215 oC
Gentiaverm
H2O Solubility
4 mg/mL
Gentiaverm
State
Solid
Gentiaverm
LogP
3.18
Gentiaverm
Dosage Forms
Liquid; Tincture
Gentiaverm
Indication
For the treatment of bacterial and fungal infections inside the mouth (thrush) and skin, also for the prevention of transmission of Chagas' disease (as a blood additive).
Gentiaverm
Pharmacology
Gentian violet is a mutagen, a mitotic poison, and a clastogen. Gentian violet has been used in medicine for almost 100 years: as an antiseptic for external use, as a topical antibiotic, as a topical antifungal agent, as an antihelminthic agent by oral administration, and more recently, as a blood additive to prevent transmission of Chagas' disease. It is thought to work by binding to the DNA of target organisms and causing disruption, mutation or inhibition of DNA replication.
Gentiaverm
Absorption
No information avaliable
Gentiaverm
side effects and Toxicity
LD50=420 mg/kg (rat, oral). Oral administration can cause gastrointestinal irritation, and intravenous injection can cause depression in the white blood cell count.
Gentiaverm
Patient Information
Gentiaverm
Organisms Affected
Yeast and other fungi, bacteria and protozoans