Hydroxyzine
Brand names,
Hydroxyzine
Analogs
Hydroxyzine
Brand Names Mixture
Hydroxyzine
Chemical_Formula
C21H27ClN2O2
Hydroxyzine
RX_link
http://www.rxlist.com/cgi/generic/hydrox.htm
Hydroxyzine
fda sheet
Hydroxyzine
msds (material safety sheet)
Hydroxyzine
Synthesis Reference
Moren; U.S. Pat. 2,899,436 (1959)
Hydroxyzine
Molecular Weight
374.904 g/mol
Hydroxyzine
Melting Point
190 oC
Hydroxyzine
H2O Solubility
< 700 mg/mL
Hydroxyzine
State
Solid
Hydroxyzine
LogP
3.036
Hydroxyzine
Dosage Forms
Capsule; Liquid; Solution; Syrup
Hydroxyzine
Indication
For symptomatic relief of anxiety and tension associated with psychoneurosis and as an adjunct in organic disease states in which anxiety is manifested. Useful in the management of pruritus due to allergic conditions such as chronic urticaria.
Hydroxyzine
Pharmacology
Hydroxyzine, a piperazine antihistamine structurally related to buclizine, cyclizine, and meclizine, is used to treat histamine-mediated pruritus or pruritus due to allergy, nausea and vomiting, and, in combination with an opiate agonist, anxiolytic pain. Hydroxyzine is also used as a perioperative sedative and anxiolytic and to manage acute alcohol withdrawal. Hydroxyzine's active metabolite, cetirizine, is also used as an H1-antagonist.
Hydroxyzine
Absorption
Rapidly absorbed from the gastrointestinal tract
Hydroxyzine
side effects and Toxicity
Oral, rat LD50: 950 mg/kg. Symptoms of overexposure include hypersedation.
Hydroxyzine
Patient Information
Hydroxyzine
Organisms Affected
Humans and other mammals