L-Adrenaline Gr
Brand names,
L-Adrenaline Gr
Analogs
L-Adrenaline Gr
Brand Names Mixture
L-Adrenaline Gr
Chemical_Formula
C9H13NO3
L-Adrenaline Gr
RX_link
http://www.rxlist.com/cgi/generic3/epi.htm
L-Adrenaline Gr
fda sheet
L-Adrenaline Gr
msds (material safety sheet)
L-Adrenaline Gr
Synthesis Reference
Stolz, Ber. 37, 4149; Payne, Ind. Chem. 37, 523
L-Adrenaline Gr
Molecular Weight
183.204 g/mol
L-Adrenaline Gr
Melting Point
211.5 oC
L-Adrenaline Gr
H2O Solubility
180 mg/L
L-Adrenaline Gr
State
Solid
L-Adrenaline Gr
LogP
0.256
L-Adrenaline Gr
Dosage Forms
Cord; Drops; Liquid; Metered-dose (aerosol); Pad; Pellet; Pellet (dental); Solution; Spray
L-Adrenaline Gr
Indication
For the treatment of anaphylactic reactions
L-Adrenaline Gr
Pharmacology
Epinephrine is indicated for intravenous injection in treatment of acute hypersensitivity, treatment of acute asthmatic attacks to relieve bronchospasm, and treatment and prophylaxis of cardiac arrest and attacks of transitory atrioventricular heart block with syncopal seizures (Stokes-Adams Syndrome). The actions of epinephrine resemble the effects of stimulation of adrenergic nerves. To a variable degree it acts on both alpha and beta receptor sites of sympathetic effector cells. Its most prominent actions are on the beta receptors of the heart, vascular and other smooth muscle. When given by rapid intravenous injection, it produces a rapid rise in blood pressure, mainly systolic, by (1) direct stimulation of cardiac muscle which increases the strength of ventricular contraction, (2) increasing the heart rate and (3) constriction of the arterioles in the skin, mucosa and splanchnic areas of the circulation. When given by slow intravenous injection, epinephrine usually produces only a moderate rise in systolic and a fall in diastolic pressure. Although some increase in pulse pressure occurs, there is usually no great elevation in mean blood pressure. Accordingly, the compensatory reflex mechanisms that come into play with a pronounced increase in blood pressure do not antagonize the direct cardiac actions of epinephrine as much as with catecholamines that have a predominant action on alpha receptors.
L-Adrenaline Gr
Absorption
Usually this vasodilator effect of the drug on the circulation predominates so that the modest rise in systolic pressure which follows slow injection or absorption is mainly the result of direct cardiac stimulation and increase in cardiac output.
L-Adrenaline Gr
side effects and Toxicity
Skin, LD50 = 62 mg/kg (rat)
L-Adrenaline Gr
Patient Information
No information avaliable
L-Adrenaline Gr
Organisms Affected
Humans and other mammals