Asthma Meter Mist
Brand names,
Asthma Meter Mist
Analogs
Asthma Meter Mist
Brand Names Mixture
Asthma Meter Mist
Chemical_Formula
C9H13NO3
Asthma Meter Mist
RX_link
http://www.rxlist.com/cgi/generic3/epi.htm
Asthma Meter Mist
fda sheet
Asthma Meter Mist
msds (material safety sheet)
Asthma Meter Mist
Synthesis Reference
Stolz, Ber. 37, 4149; Payne, Ind. Chem. 37, 523
Asthma Meter Mist
Molecular Weight
183.204 g/mol
Asthma Meter Mist
Melting Point
211.5 oC
Asthma Meter Mist
H2O Solubility
180 mg/L
Asthma Meter Mist
State
Solid
Asthma Meter Mist
LogP
0.256
Asthma Meter Mist
Dosage Forms
Cord; Drops; Liquid; Metered-dose (aerosol); Pad; Pellet; Pellet (dental); Solution; Spray
Asthma Meter Mist
Indication
For the treatment of anaphylactic reactions
Asthma Meter Mist
Pharmacology
Epinephrine is indicated for intravenous injection in treatment of acute hypersensitivity, treatment of acute asthmatic attacks to relieve bronchospasm, and treatment and prophylaxis of cardiac arrest and attacks of transitory atrioventricular heart block with syncopal seizures (Stokes-Adams Syndrome). The actions of epinephrine resemble the effects of stimulation of adrenergic nerves. To a variable degree it acts on both alpha and beta receptor sites of sympathetic effector cells. Its most prominent actions are on the beta receptors of the heart, vascular and other smooth muscle. When given by rapid intravenous injection, it produces a rapid rise in blood pressure, mainly systolic, by (1) direct stimulation of cardiac muscle which increases the strength of ventricular contraction, (2) increasing the heart rate and (3) constriction of the arterioles in the skin, mucosa and splanchnic areas of the circulation. When given by slow intravenous injection, epinephrine usually produces only a moderate rise in systolic and a fall in diastolic pressure. Although some increase in pulse pressure occurs, there is usually no great elevation in mean blood pressure. Accordingly, the compensatory reflex mechanisms that come into play with a pronounced increase in blood pressure do not antagonize the direct cardiac actions of epinephrine as much as with catecholamines that have a predominant action on alpha receptors.
Asthma Meter Mist
Absorption
Usually this vasodilator effect of the drug on the circulation predominates so that the modest rise in systolic pressure which follows slow injection or absorption is mainly the result of direct cardiac stimulation and increase in cardiac output.
Asthma Meter Mist
side effects and Toxicity
Skin, LD50 = 62 mg/kg (rat)
Asthma Meter Mist
Patient Information
No information avaliable
Asthma Meter Mist
Organisms Affected
Humans and other mammals