Intranefrin
Brand names,
Intranefrin
Analogs
Intranefrin
Brand Names Mixture
Intranefrin
Chemical_Formula
C9H13NO3
Intranefrin
RX_link
http://www.rxlist.com/cgi/generic3/epi.htm
Intranefrin
fda sheet
Intranefrin
msds (material safety sheet)
Intranefrin
Synthesis Reference
Stolz, Ber. 37, 4149; Payne, Ind. Chem. 37, 523
Intranefrin
Molecular Weight
183.204 g/mol
Intranefrin
Melting Point
211.5 oC
Intranefrin
H2O Solubility
180 mg/L
Intranefrin
State
Solid
Intranefrin
LogP
0.256
Intranefrin
Dosage Forms
Cord; Drops; Liquid; Metered-dose (aerosol); Pad; Pellet; Pellet (dental); Solution; Spray
Intranefrin
Indication
For the treatment of anaphylactic reactions
Intranefrin
Pharmacology
Epinephrine is indicated for intravenous injection in treatment of acute hypersensitivity, treatment of acute asthmatic attacks to relieve bronchospasm, and treatment and prophylaxis of cardiac arrest and attacks of transitory atrioventricular heart block with syncopal seizures (Stokes-Adams Syndrome). The actions of epinephrine resemble the effects of stimulation of adrenergic nerves. To a variable degree it acts on both alpha and beta receptor sites of sympathetic effector cells. Its most prominent actions are on the beta receptors of the heart, vascular and other smooth muscle. When given by rapid intravenous injection, it produces a rapid rise in blood pressure, mainly systolic, by (1) direct stimulation of cardiac muscle which increases the strength of ventricular contraction, (2) increasing the heart rate and (3) constriction of the arterioles in the skin, mucosa and splanchnic areas of the circulation. When given by slow intravenous injection, epinephrine usually produces only a moderate rise in systolic and a fall in diastolic pressure. Although some increase in pulse pressure occurs, there is usually no great elevation in mean blood pressure. Accordingly, the compensatory reflex mechanisms that come into play with a pronounced increase in blood pressure do not antagonize the direct cardiac actions of epinephrine as much as with catecholamines that have a predominant action on alpha receptors.
Intranefrin
Absorption
Usually this vasodilator effect of the drug on the circulation predominates so that the modest rise in systolic pressure which follows slow injection or absorption is mainly the result of direct cardiac stimulation and increase in cardiac output.
Intranefrin
side effects and Toxicity
Skin, LD50 = 62 mg/kg (rat)
Intranefrin
Patient Information
No information avaliable
Intranefrin
Organisms Affected
Humans and other mammals