Fenormin
Brand names,
Fenormin
Analogs
Fenormin
Brand Names Mixture
Fenormin
Chemical_Formula
C10H15N5
Fenormin
RX_link
No information avaliable
Fenormin
fda sheet
Fenormin
msds (material safety sheet)
Fenormin
Synthesis Reference
Shapiro, Freedman, U.S. pats. 2,961,377, 3,057,780 (1960, 1962 both to U.S.V.)
Fenormin
Molecular Weight
205.26 g/mol
Fenormin
Melting Point
175-178 oC
Fenormin
H2O Solubility
210 mg/mL
Fenormin
State
Solid
Fenormin
LogP
0.759
Fenormin
Dosage Forms
No information avaliable
Fenormin
Indication
For the reatment of type II diabetes mellitus.
Fenormin
Pharmacology
Used to treat diabetes, phenformin is a biguanide (contains 2 guanidino groups) hypoglycemic agent with actions and uses similar to those of metformin (Glucophage). Both drugs work by (1) decreasing the absorption of glucose by the intestines, (2) decreasing the production of glucose in the liver, and by (3) increasing the body's ability to use insulin more effectively. More specifically, phenformin improves glycemic control by improving insulin sensitivity. Phenformin is generally considered to be associated with an unacceptably high incidence of actic acidosis. In general biguanides should be used only in stable type II diabetics who are free of liver, kidney and cardiovascular problems and who cannot be controlled with diet.
Fenormin
Absorption
No information avaliable
Fenormin
side effects and Toxicity
No information avaliable
Fenormin
Patient Information
No information avaliable
Fenormin
Organisms Affected
Humans and other mammals