Glukopostin
Brand names,
Glukopostin
Analogs
Glukopostin
Brand Names Mixture
Glukopostin
Chemical_Formula
C10H15N5
Glukopostin
RX_link
No information avaliable
Glukopostin
fda sheet
Glukopostin
msds (material safety sheet)
Glukopostin
Synthesis Reference
Shapiro, Freedman, U.S. pats. 2,961,377, 3,057,780 (1960, 1962 both to U.S.V.)
Glukopostin
Molecular Weight
205.26 g/mol
Glukopostin
Melting Point
175-178 oC
Glukopostin
H2O Solubility
210 mg/mL
Glukopostin
State
Solid
Glukopostin
LogP
0.759
Glukopostin
Dosage Forms
No information avaliable
Glukopostin
Indication
For the reatment of type II diabetes mellitus.
Glukopostin
Pharmacology
Used to treat diabetes, phenformin is a biguanide (contains 2 guanidino groups) hypoglycemic agent with actions and uses similar to those of metformin (Glucophage). Both drugs work by (1) decreasing the absorption of glucose by the intestines, (2) decreasing the production of glucose in the liver, and by (3) increasing the body's ability to use insulin more effectively. More specifically, phenformin improves glycemic control by improving insulin sensitivity. Phenformin is generally considered to be associated with an unacceptably high incidence of actic acidosis. In general biguanides should be used only in stable type II diabetics who are free of liver, kidney and cardiovascular problems and who cannot be controlled with diet.
Glukopostin
Absorption
No information avaliable
Glukopostin
side effects and Toxicity
No information avaliable
Glukopostin
Patient Information
No information avaliable
Glukopostin
Organisms Affected
Humans and other mammals