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DB Comb Brand names, DB Comb Analogs

DB Comb Brand Names Mixture

  • No information avaliable

DB Comb Chemical_Formula


DB Comb RX_link

No information avaliable

DB Comb fda sheet

DB Comb msds (material safety sheet)

DB Comb Synthesis Reference

Shapiro, Freedman, U.S. pats. 2,961,377, 3,057,780 (1960, 1962 both to U.S.V.)

DB Comb Molecular Weight

205.26 g/mol

DB Comb Melting Point

175-178 oC

DB Comb H2O Solubility

210 mg/mL

DB Comb State


DB Comb LogP


DB Comb Dosage Forms

No information avaliable

DB Comb Indication

For the reatment of type II diabetes mellitus.

DB Comb Pharmacology

Used to treat diabetes, phenformin is a biguanide (contains 2 guanidino groups) hypoglycemic agent with actions and uses similar to those of metformin (Glucophage). Both drugs work by (1) decreasing the absorption of glucose by the intestines, (2) decreasing the production of glucose in the liver, and by (3) increasing the body's ability to use insulin more effectively. More specifically, phenformin improves glycemic control by improving insulin sensitivity. Phenformin is generally considered to be associated with an unacceptably high incidence of actic acidosis. In general biguanides should be used only in stable type II diabetics who are free of liver, kidney and cardiovascular problems and who cannot be controlled with diet.

DB Comb Absorption

No information avaliable

DB Comb side effects and Toxicity

No information avaliable

DB Comb Patient Information

No information avaliable

DB Comb Organisms Affected

Humans and other mammals