DB Comb
DB Comb Brand names, DB Comb Analogs
- Azucaps
- Beta-Pebg
- Beta-Phenethybiguanide
- Beta-Phenethylbiguanide
- Cronoformin
- D Bretard
- DBI
- DB Comb
- DB-Retard
- DBI Monohydrochloride
- Debeone
- Debinyl
- Diabis
- Dibein
- Dibiraf
- Dibotin
- Dipar
- Feguanide
- Fenfoduron
- Fenformin
- Fenformina
- Fenformina [Inn-Spanish]
- Fenormin
- Glukopostin
- Glyphen
- Insoral
- Lentobetic
- Meltrol
- Meltrol-50
- N-Phenethylbiguanide Hydrochloride
- Normoglucina
- Pedg
- Phenethylbiguanide Hydrochloride
- Phenethyldiguanide
- Phenformin HCl
- Phenformin Hydrochloride
- Phenformine
- Phenformine HCl
- Phenformine [Inn-French]
- Phenforminum [Inn-Latin]
- Phenformix
- Phenoformine Hydrochloride
- Phenylethylbiguanide
- Retardo
DB Comb Brand Names Mixture
- No information avaliable
DB Comb Chemical_Formula
C10H15N5
DB Comb RX_link
No information avaliable
DB Comb fda sheet
DB Comb msds (material safety sheet)
DB Comb Synthesis Reference
Shapiro, Freedman, U.S. pats. 2,961,377, 3,057,780 (1960, 1962 both to U.S.V.)
DB Comb Molecular Weight
205.26 g/mol
DB Comb Melting Point
175-178 oC
DB Comb H2O Solubility
210 mg/mL
DB Comb State
Solid
DB Comb LogP
0.759
DB Comb Dosage Forms
No information avaliable
DB Comb Indication
For the reatment of type II diabetes mellitus.
DB Comb Pharmacology
Used to treat diabetes, phenformin is a biguanide (contains 2 guanidino groups) hypoglycemic agent with actions and uses similar to those of metformin (Glucophage). Both drugs work by (1) decreasing the absorption of glucose by the intestines, (2) decreasing the production of glucose in the liver, and by (3) increasing the body's ability to use insulin more effectively. More specifically, phenformin improves glycemic control by improving insulin sensitivity. Phenformin is generally considered to be associated with an unacceptably high incidence of actic acidosis. In general biguanides should be used only in stable type II diabetics who are free of liver, kidney and cardiovascular problems and who cannot be controlled with diet.
DB Comb Absorption
No information avaliable
DB Comb side effects and Toxicity
No information avaliable
DB Comb Patient Information
No information avaliable
DB Comb Organisms Affected
Humans and other mammals
