D Bretard

• Hypoglycemic Agents
• ATC:A10BA01

• Azucaps
• Beta-Pebg
• Beta-Phenethybiguanide
• Beta-Phenethylbiguanide
• Cronoformin
• D Bretard
• DBI
• DB Comb
• DB-Retard
• DBI Monohydrochloride
• Debeone
• Debinyl
• Diabis
• Dibein
• Dibiraf
• Dibotin
• Dipar
• Feguanide
• Fenfoduron
• Fenformin
• Fenformina
• Fenformina [Inn-Spanish]
• Fenormin
• Glukopostin
• Glyphen
• Insoral
• Lentobetic
• Meltrol
• Meltrol-50
• N-Phenethylbiguanide Hydrochloride
• Normoglucina
• Pedg
• Phenethylbiguanide Hydrochloride
• Phenethyldiguanide
• Phenformin HCl
• Phenformin Hydrochloride
• Phenformine
• Phenformine HCl
• Phenformine [Inn-French]
• Phenforminum [Inn-Latin]
• Phenformix
• Phenoformine Hydrochloride
• Phenylethylbiguanide
• Retardo

• No information avaliable

C₁₀H₁₅N₅

No information avaliable

Shapiro, Freedman, U.S. pats. 2,961,377, 3,057,780 (1960, 1962 both to U.S.V.)

205.26 g/mol

175-178 ^oC

210 mg/mL

Solid

0.759

No information avaliable

For the reatment of type II diabetes mellitus.

Used to treat diabetes, phenformin is a biguanide (contains 2 guanidino groups) hypoglycemic agent with actions and uses similar to those of metformin (Glucophage). Both drugs work by (1) decreasing the absorption of glucose by the intestines, (2) decreasing the production of glucose in the liver, and by (3) increasing the body's ability to use insulin more effectively. More specifically, phenformin improves glycemic control by improving insulin sensitivity. Phenformin is generally considered to be associated with an unacceptably high incidence of actic acidosis. In general biguanides should be used only in stable type II diabetics who are free of liver, kidney and cardiovascular problems and who cannot be controlled with diet.

No information avaliable

No information avaliable

No information avaliable

Humans and other mammals