Phenformix
Brand names,
Phenformix
Analogs
Phenformix
Brand Names Mixture
Phenformix
Chemical_Formula
C10H15N5
Phenformix
RX_link
No information avaliable
Phenformix
fda sheet
Phenformix
msds (material safety sheet)
Phenformix
Synthesis Reference
Shapiro, Freedman, U.S. pats. 2,961,377, 3,057,780 (1960, 1962 both to U.S.V.)
Phenformix
Molecular Weight
205.26 g/mol
Phenformix
Melting Point
175-178 oC
Phenformix
H2O Solubility
210 mg/mL
Phenformix
State
Solid
Phenformix
LogP
0.759
Phenformix
Dosage Forms
No information avaliable
Phenformix
Indication
For the reatment of type II diabetes mellitus.
Phenformix
Pharmacology
Used to treat diabetes, phenformin is a biguanide (contains 2 guanidino groups) hypoglycemic agent with actions and uses similar to those of metformin (Glucophage). Both drugs work by (1) decreasing the absorption of glucose by the intestines, (2) decreasing the production of glucose in the liver, and by (3) increasing the body's ability to use insulin more effectively. More specifically, phenformin improves glycemic control by improving insulin sensitivity. Phenformin is generally considered to be associated with an unacceptably high incidence of actic acidosis. In general biguanides should be used only in stable type II diabetics who are free of liver, kidney and cardiovascular problems and who cannot be controlled with diet.
Phenformix
Absorption
No information avaliable
Phenformix
side effects and Toxicity
No information avaliable
Phenformix
Patient Information
No information avaliable
Phenformix
Organisms Affected
Humans and other mammals