Normoglucina
Brand names,
Normoglucina
Analogs
Normoglucina
Brand Names Mixture
Normoglucina
Chemical_Formula
C10H15N5
Normoglucina
RX_link
No information avaliable
Normoglucina
fda sheet
Normoglucina
msds (material safety sheet)
Normoglucina
Synthesis Reference
Shapiro, Freedman, U.S. pats. 2,961,377, 3,057,780 (1960, 1962 both to U.S.V.)
Normoglucina
Molecular Weight
205.26 g/mol
Normoglucina
Melting Point
175-178 oC
Normoglucina
H2O Solubility
210 mg/mL
Normoglucina
State
Solid
Normoglucina
LogP
0.759
Normoglucina
Dosage Forms
No information avaliable
Normoglucina
Indication
For the reatment of type II diabetes mellitus.
Normoglucina
Pharmacology
Used to treat diabetes, phenformin is a biguanide (contains 2 guanidino groups) hypoglycemic agent with actions and uses similar to those of metformin (Glucophage). Both drugs work by (1) decreasing the absorption of glucose by the intestines, (2) decreasing the production of glucose in the liver, and by (3) increasing the body's ability to use insulin more effectively. More specifically, phenformin improves glycemic control by improving insulin sensitivity. Phenformin is generally considered to be associated with an unacceptably high incidence of actic acidosis. In general biguanides should be used only in stable type II diabetics who are free of liver, kidney and cardiovascular problems and who cannot be controlled with diet.
Normoglucina
Absorption
No information avaliable
Normoglucina
side effects and Toxicity
No information avaliable
Normoglucina
Patient Information
No information avaliable
Normoglucina
Organisms Affected
Humans and other mammals