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Brand names,
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Analogs
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Brand Names Mixture
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Chemical_Formula
C10H15N5
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RX_link
No information avaliable
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
Shapiro, Freedman, U.S. pats. 2,961,377, 3,057,780 (1960, 1962 both to U.S.V.)
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Molecular Weight
205.26 g/mol
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Melting Point
175-178 oC
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H2O Solubility
210 mg/mL
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State
Solid
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LogP
0.759
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Dosage Forms
No information avaliable
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Indication
For the reatment of type II diabetes mellitus.
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Pharmacology
Used to treat diabetes, phenformin is a biguanide (contains 2 guanidino groups) hypoglycemic agent with actions and uses similar to those of metformin (Glucophage). Both drugs work by (1) decreasing the absorption of glucose by the intestines, (2) decreasing the production of glucose in the liver, and by (3) increasing the body's ability to use insulin more effectively. More specifically, phenformin improves glycemic control by improving insulin sensitivity. Phenformin is generally considered to be associated with an unacceptably high incidence of actic acidosis. In general biguanides should be used only in stable type II diabetics who are free of liver, kidney and cardiovascular problems and who cannot be controlled with diet.
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Absorption
No information avaliable
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side effects and Toxicity
No information avaliable
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Patient Information
No information avaliable
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Organisms Affected
Humans and other mammals