Fenformina
Brand names,
Fenformina
Analogs
Fenformina
Brand Names Mixture
Fenformina
Chemical_Formula
C10H15N5
Fenformina
RX_link
No information avaliable
Fenformina
fda sheet
Fenformina
msds (material safety sheet)
Fenformina
Synthesis Reference
Shapiro, Freedman, U.S. pats. 2,961,377, 3,057,780 (1960, 1962 both to U.S.V.)
Fenformina
Molecular Weight
205.26 g/mol
Fenformina
Melting Point
175-178 oC
Fenformina
H2O Solubility
210 mg/mL
Fenformina
State
Solid
Fenformina
LogP
0.759
Fenformina
Dosage Forms
No information avaliable
Fenformina
Indication
For the reatment of type II diabetes mellitus.
Fenformina
Pharmacology
Used to treat diabetes, phenformin is a biguanide (contains 2 guanidino groups) hypoglycemic agent with actions and uses similar to those of metformin (Glucophage). Both drugs work by (1) decreasing the absorption of glucose by the intestines, (2) decreasing the production of glucose in the liver, and by (3) increasing the body's ability to use insulin more effectively. More specifically, phenformin improves glycemic control by improving insulin sensitivity. Phenformin is generally considered to be associated with an unacceptably high incidence of actic acidosis. In general biguanides should be used only in stable type II diabetics who are free of liver, kidney and cardiovascular problems and who cannot be controlled with diet.
Fenformina
Absorption
No information avaliable
Fenformina
side effects and Toxicity
No information avaliable
Fenformina
Patient Information
No information avaliable
Fenformina
Organisms Affected
Humans and other mammals