Pedg
Brand names,
Pedg
Analogs
Pedg
Brand Names Mixture
Pedg
Chemical_Formula
C10H15N5
Pedg
RX_link
No information avaliable
Pedg
fda sheet
Pedg
msds (material safety sheet)
Pedg
Synthesis Reference
Shapiro, Freedman, U.S. pats. 2,961,377, 3,057,780 (1960, 1962 both to U.S.V.)
Pedg
Molecular Weight
205.26 g/mol
Pedg
Melting Point
175-178 oC
Pedg
H2O Solubility
210 mg/mL
Pedg
State
Solid
Pedg
LogP
0.759
Pedg
Dosage Forms
No information avaliable
Pedg
Indication
For the reatment of type II diabetes mellitus.
Pedg
Pharmacology
Used to treat diabetes, phenformin is a biguanide (contains 2 guanidino groups) hypoglycemic agent with actions and uses similar to those of metformin (Glucophage). Both drugs work by (1) decreasing the absorption of glucose by the intestines, (2) decreasing the production of glucose in the liver, and by (3) increasing the body's ability to use insulin more effectively. More specifically, phenformin improves glycemic control by improving insulin sensitivity. Phenformin is generally considered to be associated with an unacceptably high incidence of actic acidosis. In general biguanides should be used only in stable type II diabetics who are free of liver, kidney and cardiovascular problems and who cannot be controlled with diet.
Pedg
Absorption
No information avaliable
Pedg
side effects and Toxicity
No information avaliable
Pedg
Patient Information
No information avaliable
Pedg
Organisms Affected
Humans and other mammals