Cronoformin
Brand names,
Cronoformin
Analogs
Cronoformin
Brand Names Mixture
Cronoformin
Chemical_Formula
C10H15N5
Cronoformin
RX_link
No information avaliable
Cronoformin
fda sheet
Cronoformin
msds (material safety sheet)
Cronoformin
Synthesis Reference
Shapiro, Freedman, U.S. pats. 2,961,377, 3,057,780 (1960, 1962 both to U.S.V.)
Cronoformin
Molecular Weight
205.26 g/mol
Cronoformin
Melting Point
175-178 oC
Cronoformin
H2O Solubility
210 mg/mL
Cronoformin
State
Solid
Cronoformin
LogP
0.759
Cronoformin
Dosage Forms
No information avaliable
Cronoformin
Indication
For the reatment of type II diabetes mellitus.
Cronoformin
Pharmacology
Used to treat diabetes, phenformin is a biguanide (contains 2 guanidino groups) hypoglycemic agent with actions and uses similar to those of metformin (Glucophage). Both drugs work by (1) decreasing the absorption of glucose by the intestines, (2) decreasing the production of glucose in the liver, and by (3) increasing the body's ability to use insulin more effectively. More specifically, phenformin improves glycemic control by improving insulin sensitivity. Phenformin is generally considered to be associated with an unacceptably high incidence of actic acidosis. In general biguanides should be used only in stable type II diabetics who are free of liver, kidney and cardiovascular problems and who cannot be controlled with diet.
Cronoformin
Absorption
No information avaliable
Cronoformin
side effects and Toxicity
No information avaliable
Cronoformin
Patient Information
No information avaliable
Cronoformin
Organisms Affected
Humans and other mammals