Miostat
Brand names,
Miostat
Analogs
Miostat
Brand Names Mixture
Miostat
Chemical_Formula
C6H15N2O2+
Miostat
RX_link
http://www.rxlist.com/cgi/generic2/carbachol.htm
Miostat
fda sheet
Miostat
msds (material safety sheet)
Miostat
Synthesis Reference
No information avaliable
Miostat
Molecular Weight
147.196 g/mol
Miostat
Melting Point
210 oC
Miostat
H2O Solubility
1 g/ml
Miostat
State
Solid
Miostat
LogP
-3.78
Miostat
Dosage Forms
Liquid; Solution; Tablet
Miostat
Indication
Primarily used in the treatment of glaucoma, but is also used during ophthalmic surgery.
Miostat
Pharmacology
Carbachol is a potent cholinergic (parasympathomimetic) agent which produces constriction of the iris and ciliary body resulting in reduction in intraocular pressure. The exact mechanism by which carbachol lowers intraocular pressure is not precisely known. In the cat and rat, carbachol is well-known for its ability to induce rapid eye movement (REM) sleep when microinjected into the pontine reticular formation. Carbachol elicits this REM sleep-like state via activation of postsynaptic muscarinic cholinergic receptors (mAChRs).
Miostat
Absorption
Not well absorbed in the gastro-intestinal tract, and does not cross the blood-brain barrier.
Miostat
side effects and Toxicity
Oral, mouse: LD50 = 15 mg/kg; Oral, rat: LD50 = 40 mg/kg.
Miostat
Patient Information
No information avaliable
Miostat
Organisms Affected
Humans and other mammals