Carbyl
Brand names,
Carbyl
Analogs
Carbyl
Brand Names Mixture
Carbyl
Chemical_Formula
C6H15N2O2+
Carbyl
RX_link
http://www.rxlist.com/cgi/generic2/carbachol.htm
Carbyl
fda sheet
Carbyl
msds (material safety sheet)
Carbyl
Synthesis Reference
No information avaliable
Carbyl
Molecular Weight
147.196 g/mol
Carbyl
Melting Point
210 oC
Carbyl
H2O Solubility
1 g/ml
Carbyl
State
Solid
Carbyl
LogP
-3.78
Carbyl
Dosage Forms
Liquid; Solution; Tablet
Carbyl
Indication
Primarily used in the treatment of glaucoma, but is also used during ophthalmic surgery.
Carbyl
Pharmacology
Carbachol is a potent cholinergic (parasympathomimetic) agent which produces constriction of the iris and ciliary body resulting in reduction in intraocular pressure. The exact mechanism by which carbachol lowers intraocular pressure is not precisely known. In the cat and rat, carbachol is well-known for its ability to induce rapid eye movement (REM) sleep when microinjected into the pontine reticular formation. Carbachol elicits this REM sleep-like state via activation of postsynaptic muscarinic cholinergic receptors (mAChRs).
Carbyl
Absorption
Not well absorbed in the gastro-intestinal tract, and does not cross the blood-brain barrier.
Carbyl
side effects and Toxicity
Oral, mouse: LD50 = 15 mg/kg; Oral, rat: LD50 = 40 mg/kg.
Carbyl
Patient Information
No information avaliable
Carbyl
Organisms Affected
Humans and other mammals