Isopto Carbachol
Brand names,
Isopto Carbachol
Analogs
Isopto Carbachol
Brand Names Mixture
Isopto Carbachol
Chemical_Formula
C6H15N2O2+
Isopto Carbachol
RX_link
http://www.rxlist.com/cgi/generic2/carbachol.htm
Isopto Carbachol
fda sheet
Isopto Carbachol
msds (material safety sheet)
Isopto Carbachol
Synthesis Reference
No information avaliable
Isopto Carbachol
Molecular Weight
147.196 g/mol
Isopto Carbachol
Melting Point
210 oC
Isopto Carbachol
H2O Solubility
1 g/ml
Isopto Carbachol
State
Solid
Isopto Carbachol
LogP
-3.78
Isopto Carbachol
Dosage Forms
Liquid; Solution; Tablet
Isopto Carbachol
Indication
Primarily used in the treatment of glaucoma, but is also used during ophthalmic surgery.
Isopto Carbachol
Pharmacology
Carbachol is a potent cholinergic (parasympathomimetic) agent which produces constriction of the iris and ciliary body resulting in reduction in intraocular pressure. The exact mechanism by which carbachol lowers intraocular pressure is not precisely known. In the cat and rat, carbachol is well-known for its ability to induce rapid eye movement (REM) sleep when microinjected into the pontine reticular formation. Carbachol elicits this REM sleep-like state via activation of postsynaptic muscarinic cholinergic receptors (mAChRs).
Isopto Carbachol
Absorption
Not well absorbed in the gastro-intestinal tract, and does not cross the blood-brain barrier.
Isopto Carbachol
side effects and Toxicity
Oral, mouse: LD50 = 15 mg/kg; Oral, rat: LD50 = 40 mg/kg.
Isopto Carbachol
Patient Information
No information avaliable
Isopto Carbachol
Organisms Affected
Humans and other mammals