Carbastat intraocular
Brand names,
Carbastat intraocular
Analogs
Carbastat intraocular
Brand Names Mixture
Carbastat intraocular
Chemical_Formula
C6H15N2O2+
Carbastat intraocular
RX_link
http://www.rxlist.com/cgi/generic2/carbachol.htm
Carbastat intraocular
fda sheet
Carbastat intraocular
msds (material safety sheet)
Carbastat intraocular
Synthesis Reference
No information avaliable
Carbastat intraocular
Molecular Weight
147.196 g/mol
Carbastat intraocular
Melting Point
210 oC
Carbastat intraocular
H2O Solubility
1 g/ml
Carbastat intraocular
State
Solid
Carbastat intraocular
LogP
-3.78
Carbastat intraocular
Dosage Forms
Liquid; Solution; Tablet
Carbastat intraocular
Indication
Primarily used in the treatment of glaucoma, but is also used during ophthalmic surgery.
Carbastat intraocular
Pharmacology
Carbachol is a potent cholinergic (parasympathomimetic) agent which produces constriction of the iris and ciliary body resulting in reduction in intraocular pressure. The exact mechanism by which carbachol lowers intraocular pressure is not precisely known. In the cat and rat, carbachol is well-known for its ability to induce rapid eye movement (REM) sleep when microinjected into the pontine reticular formation. Carbachol elicits this REM sleep-like state via activation of postsynaptic muscarinic cholinergic receptors (mAChRs).
Carbastat intraocular
Absorption
Not well absorbed in the gastro-intestinal tract, and does not cross the blood-brain barrier.
Carbastat intraocular
side effects and Toxicity
Oral, mouse: LD50 = 15 mg/kg; Oral, rat: LD50 = 40 mg/kg.
Carbastat intraocular
Patient Information
No information avaliable
Carbastat intraocular
Organisms Affected
Humans and other mammals