Coletyl

Coletyl Brand names, Coletyl Analogs

Coletyl Brand Names Mixture

No information avaliable

Coletyl Chemical_Formula

C₆H₁₅N₂O₂+

Coletyl RX_link

http://www.rxlist.com/cgi/generic2/carbachol.htm

Coletyl fda sheet

Coletyl FDA

Coletyl msds (material safety sheet)

Coletyl MSDS

Coletyl Synthesis Reference

No information avaliable

Coletyl Molecular Weight

147.196 g/mol

Coletyl Melting Point

210 ^oC

Coletyl H₂O Solubility

1 g/ml

Coletyl State

Solid

Coletyl LogP

-3.78

Coletyl Dosage Forms

Liquid; Solution; Tablet

Coletyl Indication

Primarily used in the treatment of glaucoma, but is also used during ophthalmic surgery.

Coletyl Pharmacology

Carbachol is a potent cholinergic (parasympathomimetic) agent which produces constriction of the iris and ciliary body resulting in reduction in intraocular pressure. The exact mechanism by which carbachol lowers intraocular pressure is not precisely known. In the cat and rat, carbachol is well-known for its ability to induce rapid eye movement (REM) sleep when microinjected into the pontine reticular formation. Carbachol elicits this REM sleep-like state via activation of postsynaptic muscarinic cholinergic receptors (mAChRs).

Coletyl Absorption

Not well absorbed in the gastro-intestinal tract, and does not cross the blood-brain barrier.

Coletyl side effects and Toxicity

Oral, mouse: LD₅₀ = 15 mg/kg; Oral, rat: LD₅₀ = 40 mg/kg.

Coletyl Patient Information